ANTI-PCM-1 (CENTER)

Biochem/physiol Actions

Pericentriolar material 1 (PCM1) protein acts as a scaffold and facilitates the aggregation of target proteins to the centrosome during centrosome maturation. It forms a complex with Bardet-Biedl syndrome 4 protein (BBS4) and disrupted-in-schizophrenia 1 (DISC1) at the centrosome. PCM1 along with DISC1 and BBS4 plays a role in the centrosomal pathway that is associated with schizophrenia. It is involved in ciliogenesis by binding an E3 ligase enzyme to satellites. PCM1 regulates the primary cilia disassembly before mitotic entry by recruiting polo-like-kinase 1 (Plk1) to the pericentriolar matrix.

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General description

Pericentriolar material 1 (PCM1) is a centriolar satellite protein. The PCM1 gene is located on the human chromosome at 8p22.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide